Premature ageing, poor skin complexion and maybe even skin cancer could soon be a thing of the past as science discovers how to naturally correct mutated DNA.

Say goodbye to
irreversible skin
DNA damage

You’re probably familiar with the term free radicals. And maybe you already know that the sun in combination with the destructive side of the oxygen in the air you breathe is what’s ageing you and weakening your body and skin.

If not, then you should look at our article on 3 frightening facts about free radicals and oxidation in your body.

To fight these devastating processes, we rely mainly on antioxidants, which we discuss in-depth in our article What is oxidative stress and why is it ageing me? But another and perhaps lesser known – and therefore more dangerous – type of oxidative damage is when sunlight, in the presence of oxygen, directly impacts your cells’ DNA. As you know, DNA is your body’s code for how to be you: each cell reads the instructions from this blueprint and keeps you alive by doing what it’s told.

Photolyase is a newly discovered enzyme that has the power to not only protect from damage, but even reverse existing DNA damage.

DNA leads to premature ageing and disease.

If the DNA is damaged, the cell may start to do weird things. That’s a mutation, a cell that no longer follows the plan. It may stop producing enough of this, or suddenly start making too much of that, or telling the cells around it to start doing strange things, too. What we’re talking about here is a rogue cell: more often than not resulting in disease, premature ageing and, of course, cancer.

Can it be fixed?

Yes and no. There are certain types of DNA breaks that your body can fix by removing the portion of damaged DNA and replacing it with a replicate. But not all DNA damage can be fixed this way. An especially dangerous one that your body can’t fix by itself is called a dimer.

It’s the unfixable DNA “breaks” that kill

A thymine dimer is when two bases (the little steps on the DNA “ladder”) become fused together. What has happened here is that a highly charged sunray (photon) has been absorbed into the cell and the DNA, and this tiny electrical charge has forced the two bases together: they attract each other like magnets.

damaged base/“step”

Base break with backbone

Double break

Thymine dimer: two bases

stuck together

Your body can’t fix a thymine
dimer in DNA

Photolyase enters the DNA, changes the

charge and splits the bases again

DNA is now fixed, and photolyase moves
on to look for more dimers to fix

This DNA is now unreadable and, if it’s not fixed soon, you have a mutation: a cell that will start acting strangely. But your body can’t fix a dimer by itself. Humans lack a specific enzyme (found in most other plant and animal species on earth) called photolyase.

Breakthrough: how science can fix a thymine dimer

Though recently discovered, the photolyase enzyme has been clinically proven to hunt for dimers in DNA, bind to them, and then reverse the charge between the base pairs, returning them to normal.

Dr Bradley Wagemaker on photolyase and gene therapy in skincare:


Photolyase is so powerful it has even proven capable of correcting the DNA in pre-cancerous cells in patients with skin cancer. It means we are no longer just applying sunscreen, taking antioxidants and hoping for the best, we are actively going into the nucleus of the cell and reversing any damage that’s already been done, by correcting your DNA and genes. That’s true gene therapy. And very soon, you’ll be able to purchase it from your aesthetic skincare centre.

Oxidative damage summary:

•    The sun and the oxygen in the air damage our bodies, and age us. You can read about free

       radicals and their effects here

•    You can fight free radicals from the inside out with Ovelle D3 containing Pycnogenol®, 

       the most powerful antioxidant available – read more here

•    You will soon be able to reverse existing DNA damage with Helase 50 from Lamelle,

       containing the revolutionary enzyme photolyase – see more here

Lamelle’s Helase 50 containing photolyase is coming soon

Next up from Lamelle Research Laboratories is a comprehensive product that, for the first time ever, will not only prevent sun damage, but can also repair damaged DNA. Remember this name: Helase 50.

Revolutionary technologies inside Helase 50

•    Photolyase enzyme is able to bind to already damaged DNA and fix it – the first of its kind
•    Liposomal OGG-1 enzyme helps the body fix DNA damage caused by free radicals

Also inside Helase 50

•    Broad-spectrum UVR filters: SPF 50 to protect and prevent sun damage.
•    Pycnogenol®: to help absorb UV rays, supress inflammation associated with sunburn and help combat free radicals by supressing their formation and enhancing your natural antioxidants.


Coming soon

Helase 50 is brand-new, and it will be launched soon. Look out for our notifications of the launch and, in the meantime, you can sign up to be the first to know about it here.